What Is Xipere (triamcinolone ophthalmic)
XIPERE is a sterile, injectable suspension of triamcinolone acetonide, a synthetic corticosteroid for suprachoroidal use with the SCS Microinjector. Each mL of the aqueous suspension contains 40 mg of triamcinolone acetonide with 0.55% (weight/volume [w/v]) sodium chloride for tonicity, 0.5% (w/v) carboxymethylcellulose sodium, and 0.02% (w/v) polysorbate 80. It also contains potassium chloride, calcium chloride (dihydrate) and magnesium chloride (hexahydrate) as isotonicity agents, sodium acetate trihydrate(3.51 mg), sodium citrate dihydrate(1.53 mg), and water for injection. Hydrochloric acid may be used to adjust pH to a target value of 6.5. XIPERE does not contain an anti-microbial preservative.
The chemical name for triamcinolone acetonide is 9-fluoro-11β,16ɑ,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone.
XIPERE is provided as an injectable suspension in a single-dose glass vial with a rubber stopper and an aluminum seal. The SCS Microinjector is a piston syringe and a needle approximately 1 mm in length (900-µm and 1100-µm needles are included) for conducting the suprachoroidal injection.
This medication guide is specific to Xipere.
Triamcinolone ophthalmic (for the eyes) is a steroid medicine injected into the eye to treat macular edema (eye swelling) caused by uveitis in adults.
Triamcinolone ophthalmic may also be used for purposes not listed in this medication guide.
Xipere (triamcinolone ophthalmic) Side Effects
If you have symptoms of an allergic response, such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, get emergency medical attention.
Xipere may cause serious side effects. Call your doctor at once if you have:
- Eye pain or redness
- Eyes being more sensitive to light
- Vision changes
- Increased adrenal gland hormones–hunger, weight gain, swelling, slow wound healing, sweating, acne, increased body hair, tiredness, mood changes, muscle weakness, missed menstrual periods, sexual changes; or
- Decreased adrenal gland hormones–nausea, vomiting, stomach pain, loss of appetite, feeling tired or light-headed, muscle or joint pain, skin discoloration, craving salty foods.
Common side effects of Xipere may include:
- Vision changes or eye pain; or
- Increased pressure inside the eye.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Warnings
If you have an infection in or around your eye, you shouldn’t use triamcinolone.
Prior To Taking This Medication
You should not use triamcinolone ophthalmic if you are allergic to it, or if you have:
- An infection in or around your eye.
Xipere can worsen or reactivate a bacterial, viral, or fungal eye infection you already have or have recently had.
Tell your doctor if you have or have ever had:
- Diabetes
- Herpes infection of your eye
- Cataracts, glaucoma, or another condition that increases pressure inside your eyes; or
- A thyroid disorder.
Tell your doctor if you are pregnant or breastfeeding.
How Is Xipere (triamcinolone ophthalmic) Given
A medical professional injects triamcinolone ophthalmic into your eye. Before administering the injection, your doctor will numb your eye with another medication. This injection will be administered to you in a clinical setting, such as a doctor’s office.
Following the injection, you will be closely monitored for any changes in your vision, edema, inflammation, or elevated intraocular pressure.
If your symptoms worsen or do not get better, give your doctor a call.
Regular medical examinations and eye exams will be necessary.
What Happens If I Miss A Dose
If you miss your triamcinolone ophthalmic injection appointment, give your doctor a call for instructions.
What Happens If I Overdose
An overdose would be promptly handled in a medical setting.
After Taking Xipere, What Should I Avoid
Regarding any dietary, drink, or exercise limits, heed your doctor’s advice.
What Other Drugs Will Affect Xipere
Other medications you take are unlikely to interfere with medication used for the eyes. However, a lot of medications can interact. Inform your doctor about all the medications you currently take, including vitamins, herbal supplements, and both prescription and over-the-counter medications.
